No Gluten Challenge

Are you still experiencing celiac disease symptoms despite your best efforts to follow a gluten-free diet?

PROACTIVE Celiac Study is a phase 2 clinical trial testing the safety and effects of the investigational medication PRV-015. In combination with a gluten-free diet, PRV-015 aims to reduce symptoms and intestinal inflammation caused by accidental gluten exposure.

You will not be asked to ingest gluten for this study.

PRV-015 has been previously tested in about 250 people in six completed research studies. These studies show that PRV-015 has been well tolerated, and in celiac patients it may reduce inflammation in the intestine and improve the symptoms of celiac disease in those who continue to experience symptoms despite following a gluten-free diet.


  • 18-70 years old
  • Biopsy-confirmed celiac disease
  • On a gluten-free diet for at least the last 12 months
  • Still experiencing celiac disease symptoms

Study Site Locations:

  • United States (excluding Alaska and Hawaii)
Use referral code: REFCDF


Use referral code: REFCDF

About the Study Sponsor


Provention Bio, Inc., a clinical-stage biopharmaceutical company developing novel therapeutics aimed at intercepting and preventing immune-mediated diseases.