Digestive Disease Week® (DDW) is the largest international medical meeting dedicated to the science and practice of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Due to the COVID-19 crisis, DDW 2020 was cancelled, but free access to all accepted abstracts is now available at the DDW ePosters and ePapers site.
Showcasing the “brightest ideas and breakthroughs in digestive disease,” DDW 2020 includes recent studies and innovations in celiac disease and gluten-related disorders, some of which we have curated and summarized for you. To view all abstracts, select “Celiac Disease and Gluten-Related Disorders” under Topic.
TAK-101 (TIMP-GLIA) PREVENTS GLUTEN CHALLENGE INDUCED IMMUNE ACTIVATION IN ADULTS WITH CELIAC DISEASE
In this study, TAK-101 prevented an immune response to a gluten challenge in adults with celiac disease. To the authors’ knowledge, this is the first clinical trial demonstrating non-autologous induction of antigen specific tolerance in any autoimmune disease.
NON-CELIAC GLUTEN SENSITIVITY CAN BE DIFFERENTIATED FROM IRRITABLE BOWEL SYNDROME: A DIAGNOSTIC ALGORITHM
Researchers found that zonulin serum levels, combined with demographic and clinical data, may be used as a diagnostic biomarker to distinguish non-celiac gluten sensitivity (NCGS) from irritable bowel syndrome (IBS).
EXOCRINE PANCREATIC INSUFFICIENCY IS COMMON IN CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS
When examining the prevalence of exocrine pancreatic insufficiency (EPI) among celiac disease patients, researchers found that EPI affects 26% of newly diagnosed celiac patients. The researchers recommend that all celiac patients should be screened for EPI.
PROBIOTICS FOR CELIAC DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Researchers found that probiotics may improve gastrointestinal symptoms in patients with celiac disease; however, their confidence in these results was limited by the low quality of the evidence. They recommend further large clinical trials with a more rigorous design to improve the quality of the evidence.
IS A MULTIVITAMIN SUFFICIENT TO MEET NUTRITIONAL REQUIREMENTS IN CANADIAN ADULTS WITH CELIAC DISEASE FOLLOWING A GLUTEN-FREE DIET?
This study analyzed whether celiac disease patients met Recommended Dietary Allowance (RDA) targets for macro- and micro-nutrients and the effects of supplement use in reaching these targets. Adults with celiac disease met RDA targets for protein and carbohydrates, but not fiber. Those taking a calcium supplement were significantly more likely to meet RDA targets for calcium, while a multivitamin was generally sufficient to meet RDA targets for iron, Vitamin B12, and Vitamin D. Folate and fiber were below target at all time points, even with supplementation.