Research

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Recognizing Celiac Disease in Kids

As you know, celiac disease is an autoimmune disease, and it is a genetic condition that does run in families. The question is: How does one really diagnose celiac disease? It starts out, of course, with first being aware of the potential for celiac disease and therefore thinking about the symptoms. They are the classic […]

Gluten-Free, Whether You Need It or Not

Eat no wheat. That is the core, draconian commandment of a gluten-free diet, a prohibition that excises wide swaths of American cuisine – cupcakes, pizza, bread and macaroni and cheese, to name a few things. For the approximately one-in-a-hundred Americans who have a serious condition called celiac disease, that is an indisputably wise medical directive. […]

Mucosal Healing and Mortality in Coeliac Disease

Background Coeliac disease (CD), characterised by the presence of villous atrophy (VA) in the small intestine, is associated with increased mortality, but it is unknown if mortality is influenced by mucosal recovery. Aims To determine whether persistent VA is associated with mortality in CD. Methods Through biopsy reports from all pathology departments (n = 28) […]

Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing – a cohort study

Background Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD. Methods We set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I […]

Prevalence of Migraine in Patients With Celiac Disease and Inflammatory Bowel Disease

Objective: To assess the prevalence of headache in clinic and support group patients with celiac disease and inflammatory bowel disease (IBD) compared with a sample of healthy controls. Background: European studies have demonstrated increased prevalence of headache of patients with celiac disease compared with controls. Methods: Subjects took a self-administered survey containing clinical, demographic, and […]

Diagnosing Celiac Disease by Video Capsule Endoscopy (VCE) When Esophogastroduodenoscopy (EGD) and Biopsy is Unable to Provide a Diagnosis

Background: Video capsule endoscopy (VCE) is mainly used to evaluate patients with celiac disease in whom their course after diagnosis has been unfavorable and the diagnosis of adenocarcinoma, lymphoma or refractory celiac disease is entertained, but it has been suggested that VCE could replace esophagogastroduodenoscopy (EGD) and biopsy under certain circumstances. Methods: We report a […]

Multicenter Study on Season of Birth and Celiac Disease: Evidence for a New Theoretical Model of Pathogenesis

OBJECTIVE: To investigate whether season of birth is associated with celiac disease (CD). STUDY DESIGN: We performed a medical record review of 1964 patients with biopsy-proven CD at 3 teaching hospitals (2 pediatric centers and 1 adult center) between 2000 and 2010. The first positive small intestinal biopsy result defined age of diagnosis. The observed […]

Mass Screening for Celiac Disease From the Perspective of Newly Diagnosed Adolescents and Their Parents

Background: Mass screening for celiac disease (CD) as a public health intervention is controversial. Prior to implementation, acceptability to the targeted population should be addressed. We aimed at exploring adolescents’ and parents’ experiences of having the adolescents’ CD detected through mass screening, and their attitudes towards possible future mass screening. Methods: All adolescents (n = […]

Incidence of Lymphoproliferative Disorders in Patients with Celiac Disease

Prior studies describe an increased incidence of lymphoma in celiac disease. However, few studies differentiate among lymphoproliferative disorders (LPDs). Our aim was to determine incidences of LPD subtypes in celiac disease patients, describe patterns of celiac disease presentation in patients who develop LPD, and compare survival in patients with various LPD subtypes. We conducted a […]