- Why might testing the general population for these antibodies be a problem?
The test would often be inaccurate. The positive predictive value of a test depends upon what the population prevalence is. If you do this test, it’s only going to be right 30% of the time. If it’s a high-risk group, such as someone with diarrhea or a family member, it is right about 80% of the time. They’re skewed not to miss anyone.
2. Dr. Green listed some known risk factors for celiac disease. What questions might you ask him to better understand how to evaluate his statements?
Sample Answers: For these risk factors, do we know anything about causation; for example, do we know if people with a propensity toward celiac disease have more cesarean sections because of something about celiac disease? Or is it that people who have cesareans somehow become more susceptible to developing celiac disease because of something about the cesarean?
3.About what percent of the population is at risk for celiac disease?
Forty (40) percent of us have the genes and 99% or more of the population are eating gluten.
- Which of the following are risk factors for developing celiac disease?
- Being born in the summer in the northern hemisphere
- Lack of breastfeeding
- Introducing gluten to children between 4 and 6 months
- Use of iron supplements in pregnancy
- Delaying the ingestion of gluten in children until after 12 months
- Being born by cesarean section
1, 4, 6
- About 1% of the U.S. population has celiac disease. What percentage of these people has been diagnosed with the disease?
17% have been diagnosed with celiac disease.
- If you receive one positive test of transglutaminase antibody, what do current guidelines recommend you do next?
Repeat the test. The presence of one positive tissue transglutaminase antibody is not enough to put people on a gluten-free diet their entire life.
- True or False: Studies of world-class athletes from North America, USA, Canada, and Australia have shown that, even for athletes who have not been diagnosed with celiac disease, a gluten-free diet improved performance.