What is refractory sprue?

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Refractory sprue or refractory celiac disease refers to an unresponsive case of celiac disease where the villi of a patient with celiac disease do not recover even after the patient stays on a gluten-free diet. For a diagnosis of refractory sprue, all other possible causes of the intestinal damage must be eliminated. Refractory sprue affects a small percentage of people with celiac disease.

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