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Origin of celiac disease: How old are predisposing haplotypes?

We recently presented the case of a first century AD young woman, found in the archaeological site of Cosa, showing clinical signs of malnutrition, such as short height, osteoporosis, dental enamel hypoplasia and cribra orbitalia, indirect sign of anemia, all strongly suggestive for celiac disease (CD). However, whether these findings were actually associated to CD […]

Gluten Sensitivity Linked to Autism

Gluten Sensitivity Linked To Autism: findings are only a part of a very complicated puzzle The gluten free diet’s popularity has been growing in the autism community for some years but recent studies show that this approach may not be supported by clinical evidence. A recent study released on June 18, 2013, shows that a […]

CDF Medical Advisory Board Member Alessio Fasano Co-Authors Study on Stem Cell Pathways in Acute Celiac Disease

Expression Analysis of Intestinal Stem Cell Signaling Pathways in Acute Celiac Disease Background: Celiac disease is an autoimmune disease triggered by ingestion of gluten, the key proteic component of wheat, in genetically predisposed individuals. The intestinal mucosa presents lesions with varying degrees of inflammation secondary to the autoimmune insult characterized by villous atrophy and crypts […]

Drs. Joseph Murray and Peter Green [CDF Medical Avisory Board] are Among Esteemed Authors of LPM in Celiac Disease Study

Mucosal Healing and Risk of Lymphoproliferative Malignancy in Celiac Disease Outcomes Background: Celiac disease (CD) is associated with an increased risk of lymphoproliferative malignancy (LPM). It is unknown whether this risk is affected by the results of the follow-up intestinal biopsy, performed to document mucosal healing. We aimed to quantify the risk of LPM in […]

Dr. Peter Green [CDF Medical Advisory Board] Co-Authors Study on Mucosal Healing / Fracture Risk in Celiac Disease

Background: Celiac disease (CD) is associated with an increased risk of osteoporotic fracture, a risk increase that persists after diagnosis. Although the gluten-free diet results in an improvement of symptoms in the majority of patients, a significant proportion have persistent villous atrophy (VA) on follow-up biopsy. It is unknown whether persistent VA impacts long-term fracture […]

Progress Toward Oral Therapy for Celiac Disease

The world’s leading health organizations supporting celiac disease awareness and education (Celiac Disease Foundation, American Celiac Disease Alliance, Celiac Sprue Association, Gluten Intolerance Group and the National Foundation for Celiac Awareness) applaud the efforts of Alvine Pharmaceuticals and AbbVie in addressing the significant unmet medical need for therapeutic treatment of celiac disease. ALV003 is an […]

Recognizing Celiac Disease in Kids

As you know, celiac disease is an autoimmune disease, and it is a genetic condition that does run in families. The question is: How does one really diagnose celiac disease? It starts out, of course, with first being aware of the potential for celiac disease and therefore thinking about the symptoms. They are the classic […]

Gluten-Free, Whether You Need It or Not

Eat no wheat. That is the core, draconian commandment of a gluten-free diet, a prohibition that excises wide swaths of American cuisine – cupcakes, pizza, bread and macaroni and cheese, to name a few things. For the approximately one-in-a-hundred Americans who have a serious condition called celiac disease, that is an indisputably wise medical directive. […]

Mucosal Healing and Mortality in Coeliac Disease

Background Coeliac disease (CD), characterised by the presence of villous atrophy (VA) in the small intestine, is associated with increased mortality, but it is unknown if mortality is influenced by mucosal recovery. Aims To determine whether persistent VA is associated with mortality in CD. Methods Through biopsy reports from all pathology departments (n = 28) […]

Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing – a cohort study

Background Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD. Methods We set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I […]