Research

RSS feed for this section

Usefulness of Symptoms as a Diagnostic Tool for Celiac Disease

Celiac disease (CD) is the most common genetically-induced food intolerance and is thought to be present in about 1% of the world’s population. Many cases of CD go undiagnosed until adulthood but mass screening for CD for the entire population is controversial. Instead of serological (blood serum) screening for CD markers as a first step, a questionnaire could be an alternative to identifying those at risk for CD. A recent study in Sweden by Rosen et al. examined strategies for screening children for CD. Published online by Pediatrics on January 13, the study had 12-year-old children and their parents complete questionnaires about symptoms of CD and family history.

Early Feeding and Risk of Celiac Disease in a Prospective Birth Cohort

OBJECTIVES: Timing of gluten introduction has been associated with the risk of celiac disease (CD) in children, but the optimal time window is unknown. We aimed to study the effect of age of gluten introduction on the risk of CD, adjusting for continued breastfeeding. METHODS: In The Norwegian Mother and Child Cohort Study, a prospective […]

Chronic Pancreatitis

Recent findings: Celiac disease is a risk factor for pancreatitis. Patients with recurrent acute pancreatitis likely have chronic pancreatitis, do not benefit from pancreatic sphincterotomy, and may not benefit from biliary sphincterotomy. Analysis of endoscopic ultrasonography (EUS) images with an artificial neural network (ANN) program may improve chronic pancreatitis diagnosis compared with clinical interpretation of […]

Joint BSPGHAN and Coeliac UK Guidelines for the Diagnosis and Management of Celiac Disease in Children

The revised BSPGHAN guidelines for the diagnosis and management of coeliac disease represent an important shift in diagnostic strategy, aimed at simplifying and shortening the diagnostic process in selected cases. Guidance is given concerning the indications for testing for coeliac disease, which is still significantly underdiagnosed in the UK. While screening data suggest a likely […]

Gluten-Free Diet in Gluten-Related Disorders

A gluten-free diet (GFD) is recommended for all patients with coeliac disease (CD). The spectrum of gluten-related disorders in the early 1980s was simple: CD and dermatitis herpetiformis. In the last few years, wheat allergy, gluten ataxia and noncoeliac gluten sensitivity have become new gluten-related topics. Adherence to GFDs in CD is limited and factors […]

Update on the Diagnosis and Management of Refractory Coeliac Disease

A small subset of coeliac disease (CD) patients experience persisting or recurring symptoms despite strict adherence to a gluten-free diet (GFD). When other causes of villous atrophy have been excluded, these patients are referred to as refractory celiac disease (RCD) patients. RCD can be divided in two types based on the absence (type 1) or […]

Procedure volume influences adherence to celiac disease guidelines

Background Although the prevalence of celiac disease in the USA approaches 1%, most cases are undiagnosed, in part, because of low adherence to the recommendation of submitting at least four specimens during duodenal biopsy. We aimed to determine whether physician and practice characteristics are associated with adherence to this recommendation. Materials and methods We used […]

Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA

Objectives Clinical inference suggests the prevalence of non-celiac gluten sensitivity is substantially higher than that of celiac disease in the USA. Unfortunately, there are currently no data supporting these claims. The authors analyzed nationally representative data to estimate the prevalence of adherence to a gluten-free diet among participants without celiac disease and also to characterize […]