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Update on the Diagnosis and Management of Refractory Coeliac Disease

A small subset of coeliac disease (CD) patients experience persisting or recurring symptoms despite strict adherence to a gluten-free diet (GFD). When other causes of villous atrophy have been excluded, these patients are referred to as refractory celiac disease (RCD) patients. RCD can be divided in two types based on the absence (type 1) or […]

Procedure volume influences adherence to celiac disease guidelines

Background Although the prevalence of celiac disease in the USA approaches 1%, most cases are undiagnosed, in part, because of low adherence to the recommendation of submitting at least four specimens during duodenal biopsy. We aimed to determine whether physician and practice characteristics are associated with adherence to this recommendation. Materials and methods We used […]

Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA

Objectives Clinical inference suggests the prevalence of non-celiac gluten sensitivity is substantially higher than that of celiac disease in the USA. Unfortunately, there are currently no data supporting these claims. The authors analyzed nationally representative data to estimate the prevalence of adherence to a gluten-free diet among participants without celiac disease and also to characterize […]

Interest in Medical Therapy for Celiac Disease

Objectives A gluten-free diet is the treatment for celiac disease, but pharmaceutical agents are being developed. The level of interest amongst patients in using a medication to treat celiac disease is unknown. This study examined the level of interest amongst patients in medication to treat celiac disease. Methods A questionnaire was distributed to celiac disease […]

Mucosal Healing and Risk for Lymphoproliferative Malignancy in Celiac Disease

Background: Celiac disease (CD) is associated with an increased risk for lymphoproliferative malignancy (LPM). Whether this risk is affected by the results of follow-up intestinal biopsy, performed to document mucosal healing, is unknown. Objective: To examine the association between mucosal healing in CD and subsequent LPM. Design: Population-based cohort study. Setting: 28 pathology departments in […]

Celiac Disease May Increase Lymphoma Risk

SUMMARY: Persistent Villous Atrophy in Celiac Disease Patients May Increase Lymphoma Risk A recent study suggests that patients with Celiac Disease who display persistent villous atrophy are at an increased risk for certain types of lymphoma. Benjamin Lebwohl, MD, from Columbia University in New York City, and colleagues reported their findings in the August 6 […]

Origin of celiac disease: How old are predisposing haplotypes?

We recently presented the case of a first century AD young woman, found in the archaeological site of Cosa, showing clinical signs of malnutrition, such as short height, osteoporosis, dental enamel hypoplasia and cribra orbitalia, indirect sign of anemia, all strongly suggestive for celiac disease (CD). However, whether these findings were actually associated to CD […]

Gluten Sensitivity Linked to Autism

Gluten Sensitivity Linked To Autism: findings are only a part of a very complicated puzzle The gluten free diet’s popularity has been growing in the autism community for some years but recent studies show that this approach may not be supported by clinical evidence. A recent study released on June 18, 2013, shows that a […]

CDF Medical Advisory Board Member Alessio Fasano Co-Authors Study on Stem Cell Pathways in Acute Celiac Disease

Expression Analysis of Intestinal Stem Cell Signaling Pathways in Acute Celiac Disease Background: Celiac disease is an autoimmune disease triggered by ingestion of gluten, the key proteic component of wheat, in genetically predisposed individuals. The intestinal mucosa presents lesions with varying degrees of inflammation secondary to the autoimmune insult characterized by villous atrophy and crypts […]