WGO Global Guidelines on Celiac Disease

Key Diagnostic Findings Include:

  • Histopathologic changes in an intestinal biopsy, characterized by crypt hyperplasia, intraepithelial lymphocytosis, and destruction of the surface epithelial lining
  • Evidence that the small bowel enteropathy is dependent on gluten shown by positive CD-specific antibodies and/or clinical and/or histologic improvement in response to a gluten-free diet

Serological Tests Can:

  • Confirm CD in patients with a demonstrated characteristic enteropathy
  • Screen for individuals at risk
  • Identify patients in whom biopsy may be warranted.
  • Be used to identify gluten consumption during follow-up in diagnosed patients

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