Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing – a cohort study

Background
Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD.

Methods
We set out to investigate the potential use of novel serum parameters, including IL-6, IL-8, IL-17, IL-22, sCD25, sCD27, granzyme-B, sMICA and sCTLA-4 in patients diagnosed with active CD, CD on a GFD, Refractory coeliac disease (RCD) type I and II, and enteropathy associated T-cell lymphoma (EATL).

Results
In both active CD and RCDI-II elevated levels of the proinflammatory IL-8, IL-17 and sCD25 were observed. In addition, RCDII patients displayed higher serum levels of soluble granzyme-B and IL-6 in comparison to active CD patients. In contrast, no differences between RCDI and active CD or RCDII were observed. Furthermore, EATL patients displayed higher levels of IL-6 as compared to all other groups.

Conclusions
A series of novel serum parameters reveal distinctive immunological characteristics of RCDII and EATL in comparison to uncomplicated CD and RCDI.

Authors: Greetje J Tack, Roy L van Wanrooij, B Mary Von Blomberg, Hedayat Amini, Veerle M Coupe, Petra Bonnet, Chris J Mulder and Marco W Schreurs

Source: BMC Gastroenterology 2012, 12:159 doi:10.1186/1471-230X-12-159, Published: 12 November 2012